Skip to main content

Protein based covid-19 vaccine

 

A protein-based COVID-19 vaccine that mimics the shape of the virus


Posted Today

Even as several safe and effective COVID-19 vaccines are being administered to people worldwide, scientists are still hard at work developing different vaccine strategies that could provide even stronger or longer-lasting immunity against SARS-CoV-2 and its variants.


Now, researchers reporting in ACS Central Science have immunized mice with nanoparticles that mimic SARS-CoV-2 by displaying multiple copies of the receptor binding domain (RBD) antigen, showing that the vaccine triggers robust antibody and T cell responses.



Although the first vaccines to receive Emergency Use Authorization by the U.S. Food and Drug Administration were based on mRNA, more conventional protein-based vaccines have also shown promise in clinical trials. Most train the immune system to recognize the RBD, a peptide that is the portion of the SARS-CoV-2 spike protein that binds to the ACE-2 receptor on host cell surfaces.


However, not all of these vaccines elicit both antibody and T cell responses, both of which are thought to be important for longer-lasting immunity. Melody Swartz, Jeffrey Hubbell and colleagues had previously developed a vaccine delivery tool called polymersomes –– self-assembling, spherical nanoparticles that can encapsulate antigens and adjuvants (helper molecules that boost the immune response) and then release them inside immune cells. Polymersomes trigger robust T cell immunity, and the researchers wondered if they could further improve the antibody response by engineering the nanoparticles to mimic viruses by displaying multiple copies of the RBD on their surfaces.


So the team made polymersomes that were similar in size to SARS-CoV-2 and decorated them with many RBDs. After characterizing the nanoparticles in vitro, they injected them into mice, along with separate polymersomes containing an adjuvant, in two doses that were three weeks apart. For comparison, they immunized another group of mice with polymersomes that encapsulated the RBD, along with the nanoparticles containing the adjuvant. Although both groups of mice produced high levels of RBD-specific antibodies, only the surface-decorated polymersomes generated neutralizing antibodies that prevented SARS-CoV-2 infection in cells.

Both the surface-decorated and encapsulated RBDs triggered robust T cell responses. Although the new vaccine still needs to be tested for safety and efficacy in humans, it could have advantages over mRNA vaccines with regard to widespread distribution in resource-limited areas, the researchers say. That’s because the surface-decorated polymersomes are stable and active for at least 6 months with refrigeration, in contrast to mRNA vaccines that require subzero temperature storage.



Comments

Anonymous said…
🥰🥰🥰
August 12, 2021 at 6:35 PM
Post a Comment

Popular posts from this blog

Feeling of smell is our most quick admonition framework

  Feeling of smell is our most quick admonition framework The capacity to recognize and respond to the smell of a potential danger is a precondition of our and other vertebrates' endurance. Utilizing an original strategy, scientists at Karolinska Institutet have had the option to concentrate on what occurs in the cerebrum when the focal sensory system passes judgment on a smell to address risk.  The review, which is distributed in PNAS, demonstrates that negative scents related with repulsiveness or disquiet are handled sooner than positive scents and trigger an actual aversion reaction.  Delineation by Behzad Iravani/Karolinska Institutet  "The human aversion reaction to disagreeable scents related with risk has for some time been viewed as a cognizant intellectual interaction, yet our review shows interestingly that it's oblivious and incredibly quick," says the concentrate's first creator Behzad Iravani, analyst at the Division of Clinical Neuroscience, Karolin...
Post a Comment
Read more

First-in-Human Trial with CAR Macrophages Shows the Cell Therapy May Be Safe, Feasible for Solid Tumors

  First-in-Human Trial with CAR Macrophages Shows the Cell Therapy May Be Safe, Feasible for Solid Tumors Penn study exhibits that designed macrophages, which can be designated to growths, might be a potential new safe based therapy of certain tumors. Primer discoveries from Penn Medicine in a continuous first-in-human clinical preliminary looking at the security, decency and attainability of fanciful antigen receptor macrophage (CAR-M) has assisted with building up the reasonability of this inventive immunotherapy, which propels the exploring logical disclosure of CAR T cell treatment additionally spearheaded at Penn-for strong disease growths and offers a promising new technique in the battle against disease. Fundamental information from the Phase 1 multi-focus clinical preliminary, which utilizes a novel, quality based disease treatment with CAR-designed macrophages to target repetitive or metastatic HER2-positive strong growths, was introduced during the new Society for Immunot...
Post a Comment
Read more

Rocket Lab will dispatch its first Moon mission from New Zealand in late 2021

 First moon mission from New Zealand in 2021 Rocket Lab is narrowing down the details for its first Moon launch. The private spaceflight firm has revealed that its CAPSTONE mission will lift off from the company's original launch complex in New Zealand sometime in the fourth quarter of 2021. The mission was originally slated to launch in early 2021 from NASA's Wallops facility in Virginia. The CAPSTONE (Cislunar Autonomous Positioning System Technology Operations and Navigation Experiment) cubesat will serve as a vanguard for NASA's Artemis program. It will verify the propulsion needs for a highly elliptical lunar orbit, test spacecraft-to-spacecraft navigation systems and show the potential for private support in future missions. A successful mission would help NASA's future Gateway spacecraft safely approach and orbit the Moon. The launch should also represent a technical breakthrough for Rocket Lab. While the Electron rocket will serve a familiar role in carrying the...
Post a Comment
Read more